• 专利附录
  • 专利说明
  • 权利要求
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    • 专利摘要:
    source of encapsulated volatile liquid for an aerosol generating system. an aerosol generating system contains an encapsulated volatile liquid source characterized by an absorption element; a volatile liquid having a vapor pressure of at least about 20 pa at 25°C absorbed in the absorption element; and a seal having a melting point of between about 40°C and about 120°C encapsulating the absorption element. the volatile liquid contains a 2-oxo acid.
    公开号:BR112015013361B1
    申请号:R112015013361-4
    申请日:2013-12-16
    公开日:2021-08-03
    发明作者:Judith Waller；Philippe MOOR
    申请人:Philip Morris Products S.A.；
    IPC主号:
    专利说明:

    [001] The present invention relates to an encapsulated volatile liquid source for use in an aerosol generating system. The present invention especially relates to an encapsulated volatile liquid source for use in an aerosol generating system for generating an aerosol containing saline particles of nicotine.
    [002] WO 2008/121610 A1, WO 2010/107613 A1 and WO 2011/034723 A1 disclose devices and methods for delivering nicotine and other medications to a user. The devices comprise a volatile acid source or other volatile source of a delivery-enhancing compound and a source of nicotine, or other source of medication. In preferred embodiments, pyruvic acid is reacted with nicotine in the gas phase to form an aerosol of saline particles of nicotine pyruvate, which are inhaled by the user.
    [003] A sorption element with a volatile liquid sorbed on it will have a tendency to lose the volatile liquid if stored for a long period of time. In devices of the type disclosed in WO 2008/121610 A1, WO 2010/107613 A1 and WO 2011/034723 A1, it is desirable to retain sufficient volatile delivery enhancing compound and nicotine, or other medicament, during storage to generate the desired aerosol in use. It is also desirable to retain the volatile delivery enhancing compound and nicotine, or other drug, during storage, without degradation by oxidation, hydrolysis or other unwanted reactions which can alter the properties of the reactants.
    [004] It is desirable to provide an aerosol generating system for the delivery of nicotine or other medication to a user of the type disclosed in WO 2008/121610 A1, WO 2010/107613 A1 and WO 2011/034723 A1, wherein the retention of one or both of the volatile delivery enhancing compounds and the nicotine, or other drug, during storage is enhanced. It is also desirable to provide an aerosol generating system for the delivery of nicotine or other medicine to a user of the type disclosed in WO 2008/121610 A1, WO 2010/107613 A1 and WO 2011/034723 A1, wherein the stability of one or both of the volatile delivery enhancing compounds and the nicotine or other drug during storage is preserved. It is also desirable to provide an aerosol generating system for the delivery of nicotine or other medication to a user of the type disclosed in WO 2008/121610 A1, WO 2010/107613 A1 and WO 2011/034723 A1, wherein one or two volatile distribution enhancing compounds and nicotine, or another drug, are released only through the use of the aerosol generating system.
    [005] According to the present invention, there is a source of encapsulated volatile liquid characterized by: a sorption element; a volatile liquid having a vapor pressure of at least about 20 Pa at a temperature of 25°C, sorbed on the sorption element, wherein the volatile liquid contains a 2-oxo acid; and a seal with a melting point of between about 40°C and about 120°C encapsulating the sorption element.
    [006] As used herein, the term "sorbed" means that the volatile liquid is either adsorbed onto the surface of the sorption element or is absorbed into the sorption element, or both. Preferably, the volatile liquid is adsorbed onto the sorption element.
    [007] As used herein, the term "encapsulation" means that the seal forms a barrier or envelope around the sorption element.
    [008] The seal retains the sorbed volatile liquid in the sorption element and thereby considerably reduces or prevents the evaporation and loss of the volatile liquid. According to the invention, this advantageously helps to improve the retention of volatile liquid during storage of encapsulated volatile liquid sources.
    [009] The seal also insulates the sorption element with the volatile liquid sorbed on it from exposure to external atmospheric effects; in this way, it considerably reduces or prevents the reaction of the volatile liquid with oxygen and water. According to the invention, this advantageously improves the stability of the volatile liquid during storage of encapsulated volatile liquid sources.
    [0010] Preferably, the seal forms a barrier or a shell around the sorption element, which prevents contact of the volatile liquid with the atmosphere. More preferably, the seal forms a barrier or envelope around the sorption element, which prevents contact of the volatile liquid with the atmosphere and reduces or prevents exposure of the volatile liquid to light.
    [0011] Preferably, the seal forms a barrier or envelope around the sorption element that provides an environment for the volatile liquid, so that the volatile liquid remains stable after storage at room temperature, for a period of at least two months, more preferably for a period of at least four months.
    [0012] Volatile liquid can be released from the encapsulated volatile liquid source when desired by heating it to a temperature above the melting point of the seal. Heating the source of encapsulated volatile liquid above the melting point of the seal causes the seal to melt, thereby releasing the sorbed volatile liquid in the sorption element. In accordance with the present invention, therefore, encapsulated volatile liquid sources provide a means of releasing temperature-controlled volatile liquids, including compounds such as pyruvic acid and nicotine.
    Preferably, the volatile liquid has a vapor pressure of at least about 50 Pa, more preferably at least about 75 Pa, most preferably at least 100 Pa at 25°C. Unless otherwise stated, all vapor pressures referred to in this document are 25°C vapor pressures measured in accordance with ASTM E1194 - 07 standards.
    [0014] Preferably, the volatile liquid has a vapor pressure less than or equal to about 400 Pa, more preferably less than or equal to about 300 Pa, even more preferably less than or equal to about 275 Pa, more preferably less than or equal to at about 250 Pa at 25°C.
    In certain embodiments, the volatile liquid may have a vapor pressure between about 20 Pa and about 400 Pa, more preferably between about 20 Pa and 300 Pa, even more preferably between about 20 Pa and 275 Pa, more preferably between about 20 Pa and 250 Pa at 25°C.
    In other embodiments, the volatile liquid may have a vapor pressure between about 50 Pa and about 400 Pa, more preferably between about 50 Pa and 300 Pa, even more preferably between about 50 Pa and 275 Pa, more preferably between about 50 Pa and 250 Pa at 25°C.
    In additional embodiments, the volatile liquid may have a vapor pressure between about 75 Pa and about 400 Pa, more preferably between about 75 Pa and 300 Pa, even more preferably between about 75 Pa and 275 Pa, more preferably between about 75 Pa and 250 Pa at 25°C.
    In additional embodiments, the volatile liquid may have a vapor pressure between about 100 Pa and about 400 Pa, more preferably between about 100 Pa and 300 Pa, even more preferably between about 100 Pa and 275 Pa, more preferably between about 100 Pa and 250 Pa at 25°C.
    [0019] The volatile liquid may comprise a single compound. Alternatively, the volatile compound can comprise two or more different compounds.
    When the volatile liquid includes two or more different compounds, these different compounds combined have a vapor pressure of at least about 20 Pa at 25°C.
    [0021] The volatile liquid may comprise a mixture of two or more different liquid compounds.
    [0022] The volatile liquid may comprise an aqueous solution of one or more compounds. The volatile liquid may alternatively comprise a non-aqueous solution of one or more compounds.
    [0023] The volatile liquid may comprise two or more different volatile compounds. For example, the volatile liquid can comprise a mixture of two or more different volatile liquid compounds.
    [0024] Alternatively, the volatile liquid may include one or more non-volatile compounds and one or more volatile compounds. For example, the volatile liquid can comprise a solution of one or more nonvolatile compounds in a volatile solvent or a mixture of one or more nonvolatile liquid compounds and one or more volatile liquid compounds.
    [0025] The volatile liquid includes an alpha-ketoglutaric acid or a 2-oxo acid.
    [0026] In a preferred embodiment, the volatile liquid includes an acid selected from the group consisting of 3-methyl-2-oxopentanoic acid, pyruvic acid, 2-oxopentanoic acid, 4-methyl-2-oxopentanoic acid, acid 3-methyl-2-oxobutanoic acid, 2-oxo-octanoic acid and combinations thereof. In a particularly preferred embodiment, the volatile liquid includes pyruvic acid.
    [0027] The volatile liquid may additionally comprise other components, including, but not limited to, natural flavors, artificial flavors and antioxidants.
    Preferably, the sealant has a melting point between about 40°C and about 100°C, more preferably between about 40°C and about 70°C, most preferably between about 40°C and about 60°C.
    [0029] Preferably, the seal has a limited melting point range. As used herein, the term "melting point range" is used to describe the range between the temperature at which the seal begins to melt and the temperature at which it is fully melted.
    [0030] Preferably, the melting point range of the seal is less than about 10°C, more preferably it is less than about 5°C. The use of a seal with a limited melting point range allows the volatile liquid sorbed in the sorption element to be advantageously released, on demand, by heating the source of encapsulated volatile liquid.
    [0031] Volatile liquid can be released from the source of encapsulated volatile liquid at a temperature higher than the melting temperature of the seal. For example, the sealant can melt and still maintain a barrier or envelope around the volatile liquid, even if it reaches temperatures above its melting temperatures.
    [0032] The seal may solidify and re-encapsulate the volatile liquid sorbed in the sorption element, under cooling. This is advantageous when it is desired to release only a portion of the volatile liquid sorbed into the sorption element and retain the remainder of this liquid for later use.
    [0033] Preferably, the sealant contains a wax.
    [0034] Waxes are usually lipophilic, non-porous and quite opaque. A wax-containing seal may favorably form a barrier or wrap around the sorption element to prevent contact of the volatile liquid with the atmosphere and reduce or prevent its exposure to light.
    The sealant may comprise one or more natural waxes, one or more synthetic waxes, or a combination of one or more natural waxes and one or more synthetic waxes.
    The sealant may comprise one or more waxes of animal origin, one or more mineral waxes, one or more petroleum-based waxes, one or more polyolefin waxes, one or more vegetable waxes, or any combination thereof.
    Suitable waxes of animal origin include, but are not limited to, beeswax.
    [0038] Suitable petroleum-based waxes include, but are not limited to, paraffin waxes.
    Suitable polyolefin waxes include, but are not limited to, polyethylene and polypropylene waxes.
    [0040] Suitable mineral waxes include, but are not limited to, lignite wax.
    Suitable vegetable waxes include, but are not limited to, candelilla wax, carnauba wax, castor wax and soy wax.
    [0042] Preferably, the sealant contains one or more waxes selected from the group consisting of beeswax, carnauba wax, candelilla wax, petroleum waxes, polyolefin waxes and their derivatives.
    [0043] In an especially preferred embodiment, the sealant contains a paraffin wax.
    [0044] The sorption element can be made with any material or combination of suitable materials. For example, the sorption element can comprise one or more elements of glass, stainless steel, aluminum, polyethylene (PE), polypropylene, polyethylene terephthalate (PET), polybutylene terephthalate (PBT), polytetrafluoroethylene (PTFE), expanded polytetrafluoroethylene ( ePTFE) and BAREX®.
    [0045] In a preferred embodiment, the sorption element is porous.
    [0046] For example, the sorption element can be a porous element, containing one or more materials selected from the group consisting of porous plastic materials, porous polymeric fibers and porous glass fibers.
    [0047] Preferably, the sorption element is chemically inert towards the volatile liquid.
    [0048] Preferably, the sorption element is physically stable at the melting temperature of the seal.
    [0049] Preferably, the sorption element is physically stable at the temperature at which volatile liquid is released from the source of encapsulated volatile liquid.
    [0050] The sorption element can be of any suitable size and shape. In a preferred embodiment, the sorption element is a substantially cylindrical plug. In an especially preferred embodiment, the sorption element is a substantially porous cylindrical plug.
    [0051] The size, shape and composition of the sorption element can be chosen so as to allow a desired amount of volatile liquid to be sorbed into the sorption element.
    [0052] In a preferred embodiment, between about 20 µl and about 200 µl, more preferably between about 40 µl and about 150 µl, most preferably between about 50 µl and about 100 µl of the volatile liquid is sorbed into the sorption element.
    [0053] The sorption element advantageously acts as a reservoir for the volatile liquid.
    [0054] The sorption element can be encapsulated with the seal by any suitable method.
    [0055] For example, the sealant can be melted and the sorption element coated with the melted sealant; then, the molten sealant can be solidified to encapsulate the sorption element. The sorption element can be coated with the molten sealant by any suitable method such as spray, paint and fluidized coating.
    [0056] Alternatively, the seal can be melted and the sorption element immersed in it; then, the molten sealant can be solidified to encapsulate the sorption element with the sealant.
    [0057] Depending on the properties of the seal, it is possible to implement an active cooling step to solidify it at a faster rate. The inclusion of an active cooling step can favorably result in an even more uniform coating, by reducing the creep of the semi-solid seal under gravity and by reducing the seal's penetration into the sorption element. The active cooling step may comprise contacting the seal with a gaseous or liquid cooling agent. For example, the molten seal can be immersed in a container containing a liquid cooling agent, such as liquid nitrogen or cooled isopropyl alcohol; or the molten seal may also be cooled by a gaseous cooling agent such as cold air.
    [0058] The volatile liquid can be sorbed on the sorption element, before it is encapsulated by a sealant.
    [0059] Alternatively, the sorption element can be encapsulated by a seal, the volatile liquid injected through the seal into the sorption element and the injection site then sealed.
    [0060] According to the invention, there is also an aerosol generating system containing a source of encapsulated volatile liquid.
    [0061] In a preferred embodiment, there is an aerosol generating system, according to the invention, characterized by an acid source and a nicotine source, in which the acid source is a source of encapsulated volatile liquid.
    [0062] In an especially preferred embodiment, there is an aerosol generating system comprising a housing; the carcass includes: a) an inlet and an outlet that communicate with each other and are adapted so that the gaseous carrier can pass inside the carcass, through the inlet, into and out of the carcass, through the outlet; the aerosol generating system disposing in series, from the inlet to the outlet: b) a first internal area in communication with the inlet; the first inner area containing a first acid source and a nicotine source; and c) a second internal area in communication with the first; the second inner area containing a second acid source and the nicotine source, wherein the acid source is an encapsulated volatile liquid source characterized by: an sorption element; a volatile liquid having a vapor pressure of at least about 20 Pa at 25°C, sorbed on the sorption element, wherein the volatile liquid contains a 2-oxo acid and a seal having a melting point between about 40 °C and about 120°C encapsulating the sorption element.
    [0063] The aerosol generating system may additionally comprise a third indoor area in communication with the second indoor area and with the outlet.
    [0064] The aerosol generating system may additionally comprise a mouth in communication with the second or third internal area, if present, and with the outlet.
    [0065] In another preferred embodiment, there is an aerosol generating system comprising a housing; the carcass includes: a) an inlet and an outlet that communicate with each other and are adapted so that the gaseous carrier can pass inside the carcass, through the inlet, into and out of the carcass, through the outlet; the aerosol generating system having in parallel: b) a first internal area in communication with the entrance; the first inner area containing an acid source; and c) a second internal area in communication with the entrance; the second inner area containing a source of nicotine, wherein the acid source is an encapsulated volatile liquid source characterized by: an sorption element; a volatile liquid having a vapor pressure of at least about 20 Pa at 25°C sorbed into the sorption element, wherein the volatile liquid contains a 2-oxo acid and a seal having a melting point of between about 40°C and about 120°C encapsulating the sorption element. In use, a first flow of the gaseous carrier passes through the first inner area and a second flow of the gaseous carrier passes through the second inner area.
    [0066] The aerosol generating system may additionally comprise a third indoor area in communication with the first indoor area and/or the second indoor area, and with the outlet.
    [0067] The aerosol generating system may additionally comprise a mouth in communication with the first and the second internal area, or with the third internal area, if present, and with the outlet.
    [0068] In a further preferred embodiment, an aerosol generating system comprising a housing is presented; the housing includes: a) a first air inlet, a second air inlet and an outlet; the first and second air inlets are in communication with the outlet and are adapted so that the gas carrier can pass inside the carcass, through the first air inlet, inside and outside the carcass, through the outlet, and to that the gaseous carrier can pass inside the carcass, through the second air inlet, inside and outside the carcass, through the outlet; the aerosol generating system having in parallel: b) a first internal area in communication with the first input; the first inner area containing an acid source; and c) a second internal area in communication with the second air inlet; the second of the inner area containing a source of nicotine, wherein the acid source is an encapsulated volatile liquid source characterized by: an sorption element; a volatile liquid having a vapor pressure of at least about 20 Pa at 25°C sorbed into the sorption element, wherein the volatile liquid contains a 2-oxo acid and a seal having a melting point of between about 40°C and 120°C encapsulating the sorption element.
    [0069] The aerosol generating system may additionally comprise a third indoor area in communication with the first indoor area and/or the second indoor area, and with the outlet.
    [0070] The aerosol generating system may additionally comprise a mouth in communication with the first and the second internal area, or with the third internal area, if present, and with the outlet.
    [0071] The nicotine source of the aerosol generating systems can be an encapsulated nicotine source, according to the invention. The encapsulated nicotine source preferably contains a sorption element, a volatile liquid with a vapor pressure of at least about 20 Pa at 25°C sorbed into the sorption element, and a seal with a melting point of between about 40 °C and 120°C encapsulating the sorption element. Sealants and sorption elements suitable for use in encapsulated nicotine sources have been described above.
    The nicotine source may comprise one or more nicotine elements, nicotine base, a nicotine salt such as nicotine hydrochloride, nicotine bitartrate, nicotine ditartar or a nicotine derivative.
    [0073] The nicotine source may comprise natural nicotine or synthetic nicotine.
    [0074] The source of nicotine may comprise pure nicotine, a solution of nicotine in an aqueous or non-aqueous solvent, or a liquid tobacco extract.
    [0075] The nicotine source may additionally comprise an electrolyte-forming compound. The electrolyte forming compound can be selected from the group consisting of alkali metal hydroxides, alkali metal oxides, alkali metal salts, alkaline earth metal oxides, alkaline earth metal hydroxides and combinations thereof.
    [0076] For example, the nicotine source may comprise an electrolyte-forming compound selected from the group consisting of potassium hydroxide, sodium hydroxide, lithium oxide, barium oxide, potassium chloride, sodium chloride, sodium carbonate, sodium citrate, ammonium sulfate and combinations thereof.
    [0077] In certain embodiments, the nicotine source may comprise an aqueous solution of nicotine, nicotine base, a nicotine salt or a nicotine derivative, and an electrolyte-forming compound.
    [0078] According to the invention, when the aerosol generating systems comprise a third internal area, this area may comprise one or more aerosol modifying agents. For example, the third inner area may comprise a sorbent such as activated carbon, a flavoring such as menthol or their combination.
    [0079] When aerosol generating systems comprise a mouth, according to the invention, the mouth may comprise a filter. The filter may have a low or very low particle filtration efficiency.
    [0080] According to the invention, there is further provided an aerosol generating system containing a source of encapsulated volatile liquid and heating means for heating it to a temperature above the melting point of the seal.
    [0081] In a preferred embodiment, there is an aerosol generating system containing an acid source and a nicotine source, in which the acid source is a source of encapsulated volatile liquid, according to the invention; and heating means for heating the encapsulated volatile liquid source to a temperature above the melting point of the seal.
    [0082] In certain embodiments, the aerosol generating system may comprise an aerosol generating article comprising an encapsulated volatile liquid source, in accordance with the invention; and an aerosol generating device associated with the aerosol generating article, the device comprising heating means for heating the source of encapsulated volatile liquid to a temperature above the melting point of the seal.
    [0083] In certain preferred embodiments, the aerosol generating system may comprise an aerosol generating article characterized by comprising an acid source and a nicotine source, wherein the acid source is a source of encapsulated volatile liquid, in accordance with the invention; and an aerosol generating device associated with the aerosol generating article, the device comprising heating means for heating the encapsulated volatile liquid source to a temperature above the melting point of the seal.
    [0084] The heating means may be electrical and contain an electrical heater powered by a source of electrical energy supply. Where the heating means are electrical, the aerosol generating system may additionally comprise an electrical power source, such as a battery, in addition to electronic circuits configured to control the supply of electrical power supply, of the power supply source to the means of electric heating.
    [0085] Alternatively, the heating means may be non-electric, such as chemical heaters.
    [0086] According to the invention, aerosol generating systems can simulate a smoking article such as a cigar, a cigarette, a cigarillo, a pipe or a pack of cigarettes. In preferred embodiments, the aerosol generating systems simulate a cigarette in accordance with the invention.
    [0087] In certain embodiments, the housing of the aerosol generating systems can simulate a tobacco smoking article, such as a cigarette, a cigar, a cigarillo, a pipe or a pack of cigarettes, according to the invention. In certain preferred embodiments, the carcass simulates a cigarette.
    [0088] For the avoidance of doubt, features described above in relation to one aspect of the invention may also apply equally to other aspects of the invention. Generally speaking, the characteristics described above with respect to encapsulated volatile liquid sources may also relate, where appropriate, to aerosol generating systems and articles, and vice versa, in accordance with the invention.
    [0089] The use of an encapsulated volatile liquid source, according to the invention, in an aerosol generating system comprising an acid source and a nicotine source that provides a means of controlling the distribution of aerosolized salt particles of nicotine to a user, such as nicotine pyruvate particles.
    [0090] The invention will be described below, with reference to the attached drawings in which:
    [0091] Figure 1 shows a Fourier transform infrared spectrum at a wavelength of 1810 cm-1 for a source of pyruvic acid in heating, as a function of temperature, according to the invention;
    [0092] Figure 2 shows the percentage of pyruvic acid remaining in a source of pyruvic acid, according to the invention, as a function of time over a period of 30 days; and
    [0093] Figure 3 shows the yield of pyruvic acid and the average puff temperature for a source of pyruvic acid in heating, according to the invention, measured according to tobacco control criteria of the Ministry of Health of Canada. Example 1
    [0094] 50 μl of pyruvic acid is adsorbed onto a sintered porous plastic plug with a density of 0.3 g/cc, having a polybutylene terephthalate (PET) core, a polyethylene (PE) sheath and a filling of shiny viscose fiber. A suitable porous plastic plug is the Porex® XMF-0130+B (available from Porex Technologies GmbH, Germany). The porous plastic plug with 50 μl of pyruvic acid adsorbed on it is encapsulated in a paraffin wax with a melting point of 54°C to 56°C; this process occurs by melting the paraffin wax, dipping the porous plastic plug into the melted paraffin, and then solidifying the paraffin wax. A heating ramp of 3°C/minute is applied to the resulting porous plastic plug with 50 μl of pyruvic acid adsorbed thereon, encapsulated in paraffin wax; the released vapors are analyzed by Fourier Transform Infrared Spectroscopy (FTIR).
    [0095] By way of comparison, a heating ramp of 3°C/minute is also applied to an identical porous plastic plug with 50 μl of pyruvic acid adsorbed on it, which is not encapsulated in a paraffin wax and the vapors released are analyzed by FTIR spectroscopy.
    [0096] Figure 1 shows the FTIR spectrum at a wavelength of 1810 cm-1, which corresponds to the characteristic spectrum associated with pyruvic acid, for (a) the porous plastic plug with 50 μl of pyruvic acid adsorbed on it, encapsulated in paraffin wax, and for (b) the porous plastic plug with 50 μl of pyruvic acid adsorbed on it, not encapsulated in paraffin wax.
    [0097] As shown in Figure 1, the porous plastic plug with 50 μl of pyruvic acid adsorbed on it, encapsulated in paraffin wax, does not release pyruvic acid up to approximately 70°C. On the other hand, the porous plastic plug with 50 μl of pyruvic acid adsorbed on it, not encapsulated in paraffin wax, releases the pyruvic acid immediately on heating. Example 2
    [0098] Example 1 is repeated using beeswax instead of paraffin wax.
    [0099] A heating ramp of 3°C/minute is applied to the resulting porous plastic plug with 50 μl of pyruvic acid adsorbed on it, encapsulated in beeswax; the released vapors are analyzed by Fourier Transform Infrared Spectroscopy (FTIR).
    [00100] By way of comparison, a heating ramp of 3°C/minute is also applied to an identical porous plastic plug with 50 μl of pyruvic acid adsorbed on it, which is not encapsulated in beeswax and the vapors released are analyzed by FTIR spectroscopy.
    [00101] The porous plastic plug with 50 μl of pyruvic acid adsorbed on it, encapsulated in beeswax, does not release pyruvic acid up to approximately 80°C. On the other hand, the porous plastic plug with 50 μl of pyruvic acid adsorbed on it, not encapsulated in beeswax, releases the pyruvic acid immediately on heating. Example 3
    [00102] Example 1 is repeated using carnauba wax instead of paraffin wax.
    [00103] A heating ramp of 3°C/minute is applied to the resulting porous plastic plug with 50 μl of pyruvic acid adsorbed on it, encapsulated in carnauba wax; the released vapors are analyzed by Fourier Transform Infrared Spectroscopy (FTIR).
    [00104] By way of comparison, a heating ramp of 3°C/minute is also applied to an identical porous plastic plug with 50 μl of pyruvic acid adsorbed on it, which is not encapsulated in carnauba wax and the vapors released are analyzed by FTIR spectroscopy.
    [00105] The porous plastic plug with 50 μl of pyruvic acid adsorbed on it, encapsulated in carnauba wax, does not release pyruvic acid up to approximately 100°C. On the other hand, the porous plastic plug with 50 μl of pyruvic acid adsorbed on it, not encapsulated in carnauba wax, releases the pyruvic acid immediately upon heating. Example 4
    [00106] 50 μl of pyruvic acid are adsorbed onto a sintered porous plastic plug with a density of 0.17 g/cc, having a core of polyethylene terephthalate (PET) and a sheath of polyethylene (PE). A suitable porous plastic plug is the Porex® XMF-0507 (available from Porex GmbH, Germany). The porous plastic plug with 50 μl of pyruvic acid adsorbed on it is encapsulated in a paraffin wax with a melting point of 54°C to 56°C; This process takes place by melting the paraffin wax, dipping the porous plastic plug into the melted paraffin, and then solidifying the paraffin wax. The resulting porous plastic plug with 50 μl of pyruvic acid adsorbed on it, encapsulated in paraffin wax, is stored at 22°C and 50% relative humidity; its mass is measured over a period of 30 days.
    [00107] By way of comparison, an identical porous plastic plug with 50 μl of pyruvic acid adsorbed on it, not encapsulated in paraffin wax, is also stored at 22°C and 50% relative humidity and its mass is measured at over a period of 30 days.
    [00108] Figure 2 shows the percentages of remaining pyruvic acid estimated by the total mass loss in (a) porous plastic plug with 50 μl of pyruvic acid adsorbed on it, encapsulated in paraffin wax, and in (b) plug of porous plastic with 50 μl of pyruvic acid adsorbed on it, not encapsulated in paraffin wax.
    [00109] As shown in Figure 2, the porous plastic plug with 50 μl of pyruvic acid adsorbed on it, encapsulated in paraffin wax, does not show any loss of pyruvic acid over a 30-day period. On the other hand, the porous plastic plug with 50 μl of pyruvic acid adsorbed on it, not encapsulated in paraffin wax, loses more than 80% of the pyruvic acid in 10 days. Example 5
    [00110] 50 μl of pyruvic acid are adsorbed onto a sintered porous plastic plug with a density of 0.17 g/cc, having a core of polyethylene terephthalate (PET) and a sheath of polyethylene (PE). A suitable porous plastic plug is the Porex® XMF-0507 (available from Porex GmbH, Germany). The porous plastic plug with 50 μl of pyruvic acid adsorbed on it is encapsulated in a paraffin wax with a melting point of 54°C to 56°C; This process takes place by melting the paraffin wax, dipping the porous plastic plug into the melted paraffin, and then solidifying the paraffin wax.
    [00111] The resulting porous plastic plug with 50 μl of pyruvic acid adsorbed on it, encapsulated in paraffin wax, is heated to a temperature of 75°C and the yield of pyruvic acid per group of five puffs is measured, according to the criteria of Health Canada tobacco control for more than 20 puffs, with a puff volume of 55 ml, puff duration of 2 seconds, and a 30-second interval between puffs.
    [00112] An identical porous plastic plug, with 50 μl of pyruvic acid adsorbed on it, encapsulated in paraffin wax, is stored at 22°C and 50% relative humidity for a period of 30 days; it is then heated to a temperature of 75°C and the yield of pyruvic acid per group of five puffs is measured, according to Health Canada tobacco control criteria, for more than 20 puffs, with the puff volume being of 55 ml, puff duration of 2 seconds and a 30-second interval between puffs.
    [00113] By way of comparison, an identical porous plastic plug with 50 μl of pyruvic acid adsorbed on it, not encapsulated in paraffin wax, is heated to a temperature of 75°C and the yield of pyruvic acid per group of five puffs is measured, according to Health Canada Tobacco Control Criteria, for more than 20 puffs, with the puff volume being 55 ml, the puff duration being 2 seconds, and a puff interval of 30 seconds.
    [00114] Figure 3 shows the yield of pyruvic acid and the average puff temperature per group of five puffs of (a) porous plastic plug with 50 μl of pyruvic acid adsorbed on it, not encapsulated in paraffin wax, from (b) porous plastic plug with 50 μl of pyruvic acid adsorbed on it, encapsulated in paraffin wax, and (c) porous plastic plug with 50 μl of pyruvic acid adsorbed on it, encapsulated in paraffin wax and stored by 30 days.
    [00115] As shown in Figure 3, the yield of pyruvic acid in the first group of five puffs for (b) porous plastic plug with 50 μl of pyruvic acid adsorbed on it, encapsulated in paraffin wax, and for ( c) porous plastic plug with 50 μl of pyruvic acid adsorbed on it, encapsulated in paraffin wax and stored for 30 days is inferior to (a) porous plastic plug with 50 μl of pyruvic acid adsorbed on it, not encapsulated in wax paraffin. This is because pyruvic acid is released from (b) porous plastic plug with 50 μl of pyruvic acid adsorbed on it, encapsulated in paraffin wax, and from (c) porous plastic plug with 50 μl of pyruvic acid adsorbed on it , encapsulated in paraffin wax and stored for 30 days, only when the melting point of the paraffin wax (shown by the dashed line in Figure 3) is reached, which does not occur until about the fourth puff. As also shown in Figure 3, the yield of pyruvic acid from (c) porous plastic plug with 50 μl of pyruvic acid adsorbed on it, encapsulated in paraffin wax and stored for 30 days, is similar to that of (b) plug of porous plastic with 50 μl of pyruvic acid adsorbed on it, encapsulated in paraffin wax. This indicates that the pyruvic acid is prolonged stored in the porous plastic plug encapsulated in paraffin wax over a period of 30 days.
    [00116] As illustrated by the previous examples, it is possible to control the release of a volatile liquid containing a 2-oxo acid, such as pyruvic acid, according to the invention, by controlling the encapsulation of a sorption element, in which the liquid volatile is slurried. With the use of a sealant, such as, but not limited to, a wax, for example, paraffin wax, of a certain melting point for the encapsulation of a sorption element, such as, but not limited to, a plug of porous plastic with a volatile liquid sorbed on it, provides a temperature-controlled means of releasing the volatile liquid.
    [00117] The invention was exemplified above with reference to porous plastic plugs, such as Porex® plugs, having pyruvic acid adsorbed on them and being encapsulated in paraffin, bee or carnauba wax. However, it should be noted that encapsulated volatile liquid sources may comprise other adsorption elements, other volatile liquids comprising 2-oxo acid and other sealants, in accordance with the invention.
    权利要求:
    Claims (12)
    [0001]
    1. Aerosol generating system, characterized by the fact that it comprises: an acid source; and a nicotine source, wherein the nicotine source is an encapsulated nicotine source, and wherein the acid source is an encapsulated volatile liquid source comprising: an sorption element; a volatile liquid having a vapor pressure of at least about 20 Pa at 25°C sorbed on the sorption element, wherein the volatile liquid comprises a 2-oxo acid; and a seal with a melting point of between about 40°C and about 120°C encapsulating the sorption element.
    [0002]
    2. System according to claim 1, characterized in that the volatile liquid has a vapor pressure of at least about 50 Pa at 25°C.
    [0003]
    3. System according to claim 1 or 2, characterized in that the acid is selected from the group consisting of 3-methyl-2-oxovaleric acid, pyruvic acid, 2-oxovaleric acid, acid 4-methyl-2-oxovaleric acid, 3-methyl-2-oxobutanoic acid, 2-oxo-octanoic acid and combinations thereof.
    [0004]
    4. System according to claim 3, characterized in that the acid is a pyruvic acid.
    [0005]
    5. System according to any one of claims 1 to 4, characterized in that the seal has a melting point between about 40°C and about 70°C.
    [0006]
    6. System according to any one of claims 1 to 5, characterized in that the sealant comprises a wax.
    [0007]
    7. System according to claim 6, characterized in that the sealant comprises one or more waxes selected from the group consisting of beeswax, carnauba wax, candelilla wax, petroleum waxes, polyolefin waxes and derived from them.
    [0008]
    8. System according to claim 7, characterized in that the sealant comprises a paraffin wax.
    [0009]
    9. System according to any one of claims 1 to 8, characterized in that the sorption element is a porous adsorption element.
    [0010]
    10. System according to any one of claims 1 to 9, characterized in that it further comprises: heating means to heat the source of encapsulated volatile liquid to a temperature above the melting point of the seal.
    [0011]
    11. System according to any one of claims 1 to 10, characterized in that it simulates a cigarette.
    [0012]
    12. System according to any one of claims 1 to 11, characterized in that the nicotine source is an encapsulated nicotine source comprising: a sorption element; a volatile liquid having a vapor pressure of at least about 20 Pa at 25°C sorbed on the sorption element; and a seal having a melting point between about 40°C and about 120°C encapsulating the sorption element.
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    同族专利:
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    CN104822281B|2018-11-02|
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    KR102199555B1|2021-01-08|
    RU2015129547A|2017-01-23|
    JP6608701B2|2019-11-20|
    CN104822281A|2015-08-05|
    JP2016500272A|2016-01-12|
    BR112015013361A2|2017-07-11|
    RU2660306C2|2018-07-05|
    AR094058A1|2015-07-08|
    EP2934198B1|2020-04-22|
    KR20150097579A|2015-08-26|
    EP2934198A1|2015-10-28|
    WO2014095701A1|2014-06-26|
    TW201427719A|2014-07-16|
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    法律状态:
    2018-03-06| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|
    2018-03-13| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|
    2018-03-20| B06I| Publication of requirement cancelled [chapter 6.9 patent gazette]|Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA. |
    2019-10-15| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|
    2019-12-03| B06I| Publication of requirement cancelled [chapter 6.9 patent gazette]|Free format text: ANULADA A PUBLICACAO CODIGO 6.21 NA RPI NO 2545 DE 15/10/2019 POR TER SIDO INDEVIDA. |
    2019-12-10| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|
    2021-05-25| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2021-08-03| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 16/12/2013, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    EP12197848.0|2012-12-18|
    EP12197848|2012-12-18|
    PCT/EP2013/076673|WO2014095701A1|2012-12-18|2013-12-16|Encapsulated volatile liquid source for an aerosol-generating system|
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